CVS Health

2015 Revenue: $177.5 billion

CVS(cvs, -0.34%) struggled to get consumers through its door in 2016. Some observers trace those woes back to 2014—when the retail and pharmacy chain said it would stop selling cigarettes. While that meant $2 billion less in annual sales, CVS’s top brass seemed convinced that the new strategy forward would eventually be better for its financial health, too. More recently, CVS has emphasized its beauty and health sections, in an effort to draw more retail traffic.