“Will & Grace”

NBC
1998 – present

Groundbreaking for all the right reasons, David Kohan and Max Mutchnick’s network multi-camera sitcom joined the ranks of NBC when their Thursday night lineup was still bonafide Must-See TV — and lived up to its slogan. The titular best friends played by Debra Messing and Eric McCormack made up half a winning casting combo, as Sean Hayes and Megan Mullally provided such iconic character work, it’s no wonder people still see them as Jack McFarland and Karen Walker to this day. Ellen may have made history by coming out on TV a year earlier, but “Will & Grace” opened more minds than we’ll ever know, and earned more laughs than anyone could count.